CH-50:
Why CH-50 Test?
CLINICAL INFORMATION
Complement proteins are a part of innate immunity that regulates enzymes of the complement, coagulation, fibrinolytic and kinin-forming systems. Their deficiency and/or disorders are found to be associated with autoimmune diseases such as lympho-proliferative disease, lupus erythematosis, rheumatoid arthritis, etc. The clinical manifestations include recurrent infections (due to conditions like acquired immunodeficiency syndrome) that lead to immuno -compromised states. The total complement activity is (also known as CH-50 as well CH – 100) a screening assay for the activation of the classical complement pathway. Hence its reduction or absence or inactivity becomes a crucial component in its cascade pathway. Elevated levels of CH-50 are an indication, suggesting the presence of immune activation eg. active inflammation indicative of certain conditions such as leukemia or non-Hodgkin lymphoma, ulcerative colitis, etc. While low or undetectable CH-50 indicates either complete deficiency of any complement component of the immune system eg. lupus erythematosis. Conditions that are associated with low complement activity include lupus, rheumatoid arthritis, chirrosis, kidney diseases, hereditary angioedema, malnutrition, recurrent infections (especially bacteria), etc. CH-50 test also known as CH-50 lab is a functional test that helps measure the function of (complement proteins) the complete classical complement pathway, mediated by components C1 to C9 (when CH-50 test shows abnormal functional test results, then each of the nine different complement levels can be measured individually/ together as a confirmatory test). Hence this CH-50 test result screens for hereditary or acquired deficiencies related to the complement proteins that facilitate the immune system. Clinical manifestations of altered complement proteins leading to disorders of the immune system include malar rash (lupus), fatigue, mouth sores, hair loss, sensitivity to sunlight, swollen lymph nodes, chest pain while deep breathing, joint pains, recurrent fevers, etc.
General Instructions:
Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
Sample Requirement: Blood Sample taken from the vein
Test Preparation: None
This Multi-Specialty Clinical Referral Laboratory RT DIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
