CD-30 IHC MARKER:
CLINICAL INFORMATION
Why CD30 IHC Marker Test?
CD 30 is also known as CD30L receptor, Ber-H2, Ki-1, D1S166E, Lymphocyte activation antigen 30, Member 8, cytokine receptor CD 30, CD 30 antigen. CD 30 is a member of the tumor necrosis factor (TNF-R) superfamily (especially receptor superfamily member 8 -TNFRSF8 orTNFR8 and CD 30 – both are cell surface glycoproteins and their receptor families are recognized by cysteine-rich extracellular domains). Expression of CD 30 can also be seen in embryonal carcinomas, malignant melanomas, mesenchymal tumors, activated T and B lymphocytes (they are not found on resting native lymphocytes), plasma cells, memory cells, and also on a few other normal cells (Its the restricted expression on normal cells makes it an attractive candidate for targeted therapy). Its signaling activates NF-ᴋB transcription factor, resulting in pleiotropic regulation of gene function. Reed-Sternberg cells of classic Hodgkin lymphoma as well as the neoplastic cells of anaplastic large cell lymphoma, express CD 30. Hence CD30 IHC Marker Test helps as the characteristic marker of the classical Hodgkin lymphoma, anaplastic large cell lymphoma, immunoblastic B cell, embryonic carcinoma, and also is expressed on a subset of aggressive T and B cell neoplasms.
General Instructions:
Sample Requirement: Specimen - Blood sample collected from the vein. Test Preparation: None.
NOTE - Sample for specimen collections may vary based on the patient’s condition/cases according to the patient’s presenting complaints/signs or symptoms:
SPECIMEN REQUIREMENT (Special or Rare Cases) - As instructed and guided by Physician / Clinician / Pathologist / as per Laboratory’s requirements, according to procedures and protocols.
Sample Requirement: Blood Sample taken from the vein
Test Preparation: None
This Multi-Specialty Clinical Referral Laboratory RT DIAGNOSTICS provides precise and accurate tests with an extensive range of testing services to the medical centers to help in the diagnosis and identification of pathology in the test specimens for infectious diseases and also to evaluate the function of organ systems of the patient. It prevents further complications and helps to stabilize and restore health to near normalcy at the earliest without delay.
